Quantifying the impact of weak, strong, and super ties in scientific careers

Scientists are frequently faced with the important decision to start or terminate a creative partnership. This process can be influenced by strategic motivations, as early career researchers are pursuers, whereas senior researchers are typically attractors, of new collaborative opportunities. Focusing on the longitudinal aspects of scientific collaboration, we analyzed 473 collaboration profiles using an ego-centric perspective which accounts for researcher-specific characteristics and provides insight into a range of topics, from career achievement and sustainability to team dynamics and efficiency. From more than 166,000 collaboration records, we quantify the frequency distributions of collaboration duration and tie-strength, showing that collaboration networks are dominated by weak ties characterized by high turnover rates. We use analytic extreme-value thresholds to identify a new class of indispensable `super ties', the strongest of which commonly exhibit >50% publication overlap with the central scientist. The prevalence of super ties suggests that they arise from career strategies based upon cost, risk, and reward sharing and complementary skill matching. We then use a combination of descriptive and panel regression methods to compare the subset of publications coauthored with a super tie to the subset without one, controlling for pertinent features such as career age, prestige, team size, and prior group experience. We find that super ties contribute to above-average productivity and a 17% citation increase per publication, thus identifying these partnerships - the analog of life partners - as a major factor in science career development.Comment: 13 pages, 5 figures, 1 Tabl

Had i politiske debatter online og offline: Hvem står for hadet – og hvem rammer hadet?

Hadefuld adfærd på de sociale medier i forbindelse med eksempelvis politiske diskussioner anses for et stigende samfundsproblem. I denne artikel spørger vi: Hvem er udøverne af det politiske had på internettet – og hvem er ofrene? Og er udøverne af og ofrene for had anderledes på internettet end udenfor internettet? Analyserne viser, at de personer, som optræder hadefuldt og rammes af had i forbindelse med politiske diskussioner, i høj grad er de samme både online og offline. Aggressiv adfærd er generelt mere udbredt blandt unge mænd, og analyserne viser, at det også først og fremmest er unge mænd, der optræder hadefuldt både online og offline. I overensstemmelse med viden om aggression generelt retter hadet sig også først og fremmest mod andre unge mænd. Internethad ser således ikke ud til at være en særlig form for had eller aggressivitet. De, der er aggressive offline, er også aggressive online, og de går efter de samme ofre begge steder

RMSE is not enough: Guidelines to robust data-model comparisons for magnetospheric physics

This is a review article of recent data-model comparison methodologies used in magnetospheric physics studies, also presenting a systematic categorization of these metrics for robust usage and augmented scientific output.The magnetospheric physics research community uses a broad array of quantitative data-model comparison methods (metrics) when conducting their research investigations. It is often the case, though, that any particular study will only use one or two metrics, with the two most common being Pearson correlation coefficient and root mean square error (RMSE). Because metrics are designed to test a specific aspect of the data-model relationship, limiting the comparison to only one or two metrics reduces the physical insights that can be gleaned from the analysis, restricting the possible findings from modeling studies. Additional physical insights can be obtained when many types of metrics are applied. We organize metrics into two primary groups: 1) fit performance metrics, often based on the data-model value difference; and 2) event detection metrics, which use a discrete event classification of data and model values determined by a specified threshold. In addition to these groups, there are several major categories of metrics based on the aspect of the data-model relationship that the metric assesses: 1) accuracy; 2) bias; 3) precision; 4) association; 5) and extremes. Another category is skill, which is a measure of any of these metrics against the performance of a reference model. These can be applied to a subset of either the data or the model values, known as reliability and discrimination assessments. In the context of magnetospheric physics examples, we discuss best practices for choosing metrics for particular studies.The authors would like to thank the US government for sponsoring this research, in particular research grants from NASA (NNX17AB87G, NNX16AQ04G, 80NSSC17K0015) and NSF (1663770). This study received partial funding from the European Union Horizon 2020 Research and Innovation Programme under grant agreement 870452 (PAGER). A. Azari’s contributions are based on work supported by the NSF Graduate Research Fellowship Program (DGE 1256260), A. Mukhopadhyay’s contributions are based on work supported by the NASA Future Investigator fellowship 80NSSC18K1120. B. Swiger’s contributions were partially supported by the NASA Future Investigator fellowship number 80NSSC20K1504. Data for Fig. 3 is available at the University of Michigan Deep Blue Data Repository, https://doi. org/10.7302/Z25T3HQC. Figures in section 4 are reused with permission.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/171097/1/Liemohn_JASTP_2021_RMSEisnotEnough.pdfDescription of Liemohn_JASTP_2021_RMSEisnotEnough.pdf : Main articleSEL

Introducing a pole concept for nodule growth in the thyroid gland: taller-than-wide shape, frequency, location and risk of malignancy of thyroid nodules in an area with iodine deficiency

Purpose : (i) To examine the criterion taller-than-wide (TTW) for the sonographic assessment of thyroid nodules in areas of iodine deficiency in terms of frequency, anatomical distribution within the thyroid gland and risk of malignancy. (ii) To develop a model for nodule growth in the thyroid gland. Methods: German multicenter study consisting of two parts. In the prospective part, thyroid nodules were sonographically measured in all three dimensions, location within the thyroid gland and contact to a protrusion-like formation (horn) in the dorsal position of thyroid gland was noted. In addition, further sonographic features such as the composition, echogenity, margins and calcifications were investigated. All nodules from the prospective part were assessed for malignancy as part of clinical routine at the decision of the treating physician adhering to institutionally based algorithms. In the retrospective part, only nodules with fine needle aspiration and/or histology were included. The risk of malignancy in TTW nodules was determined by correlating them with cyotological and histological results. Results: Prospective part: out of 441 consecutively evaluated thyroid nodules, 6 were found to be malignant (1.4%, 95% CI 0.6–2.7%). Among the 74 TTW nodules (17%), 1 was malignant (1%, 95% CI 0–4%). TTW nodules were more often located in the dorsal half of the thyroid than non-TTW nodules (factor 2.3, p = 0.01, 95% CI 2.1–2.5) and more often located in close proximity to a horn than non-TTW nodules (factor 3.0, p = 0.01, 95% CI 2.4–3.8). Retrospective part: out of 1315 histologically and/or cytologically confirmed thyroid nodules, 163 TTW nodules were retrieved and retrospectively analyzed. A TTW nodule was 1.7 times more often benign when it was dorsal (95% CI 1.1–2.5) and 2.5 times more often benign when it was associated with a horn (95% CI 1.2–5.3). The overall probability of malignancy for TTW nodules was 38% (95% CI 30–46%) in this highly preselected patient group. Conclusion: TTW nodules are common in iodine deficient areas. They are often located in the dorsal half of the thyroid gland and are frequently associated with a dorsal protrusion-like formation (horn) of the thyroid. Obviously, the shape of benign nodules follows distinct anatomical preconditions within the thyroid gland. The frequency of TTW nodules and their predominant benignity can be explained by a pole concept of goiter growth. The difference between the low malignancy risk of TTW nodules found on a prospective basis and the high risk found retrospectively may be the result of a positive preselection in the latter

Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development.

Cellular ATP is mainly generated through mitochondrial oxidative phosphorylation, which is dependent on mitochondrial DNA (mtDNA). We have previously demonstrated the importance of oocyte mtDNA for porcine and human fertilization. However, the role of nuclear-encoded mitochondrial replication factors during oocyte and embryo development is not yet understood. We have analyzed two key factors, mitochondrial transcription factor A (TFAM) and polymerase gamma (POLG), to determine their role in oocyte and early embryo development. Competent and incompetent oocytes, as determined by brilliant cresyl blue (BCB) dye, were assessed intermittently during the maturation process for TFAM and POLG mRNA using real-time RT-PCR, for TFAM and POLG protein using immunocytochemistry, and for mtDNA copy number using real-time PCR. Analysis was also carried out following treatment of maturing oocytes with the mtDNA replication inhibitor, 2',3'-dideoxycytidine (ddC). Following in vitro fertilization, preimplantation embryos were also analyzed. Despite increased levels of TFAM and POLG mRNA and protein at the four-cell stage, no increase in mtDNA copy number was observed in early preimplantation development. To compensate for this, mtDNA appeared to be replicated during oocyte maturation. However, significant differences in nuclear-encoded regulatory protein expression were observed between BCB(+) and BCB(-) oocytes and between untreated oocytes and those treated with ddC. These changes resulted in delayed mtDNA replication, which correlated to reduced fertilization and embryonic development. We therefore conclude that adherence to the regulation of the timing of mtDNA replication during oocyte maturation is essential for successful embryonic development

Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment

Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer’s disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI

EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.

Hydrops fetalis describes fluid accumulation in at least 2 fetal compartments, including abdominal cavities, pleura, and pericardium, or in body tissue. The majority of hydrops fetalis cases are nonimmune conditions that present with generalized edema of the fetus, and approximately 15% of these nonimmune cases result from a lymphatic abnormality. Here, we have identified an autosomal dominant, inherited form of lymphatic-related (nonimmune) hydrops fetalis (LRHF). Independent exome sequencing projects on 2 families with a history of in utero and neonatal deaths associated with nonimmune hydrops fetalis uncovered 2 heterozygous missense variants in the gene encoding Eph receptor B4 (EPHB4). Biochemical analysis determined that the mutant EPHB4 proteins are devoid of tyrosine kinase activity, indicating that loss of EPHB4 signaling contributes to LRHF pathogenesis. Further, inactivation of Ephb4 in lymphatic endothelial cells of developing mouse embryos led to defective lymphovenous valve formation and consequent subcutaneous edema. Together, these findings identify EPHB4 as a critical regulator of early lymphatic vascular development and demonstrate that mutations in the gene can cause an autosomal dominant form of LRHF that is associated with a high mortality rate